Abstract 9

Treatment of Still disease in adults with intravenous
immunoglobulins

Permal S Wechsler B Cabane J
Perrot S Blum L Imbert JC

Traitement de la maladie de Still de l'adulte par immunoglobulines
intraveineuses.

In: Rev Med Interne (1995) 16(4):250-4

ISSN: 0248-8663 (Published in French)

In most cases, the treatment of adult's Still disease presents difficulties, in view of its undesirable side-effects. For this reason, we made an open trial of the effects of high-dose intravenous immunoglobulins (IVIg), a therapy with low iatrogen risk, and whose effectiveness in the treatment of other multisystemic diseases has
been acknowledged. Seven patients suffering from adult Still's disease were given between one and eight IVIg infusions with a dose
of 1 g/kg/day for two consecutive days. All seven responded positively, with clinical improvement. It lasted between 1 and 90
days in three patients, who subsequently relapsed; it has been continuing for an average of 13 months (2 to 24 months) in the other
four patients. There were no clinical features making it possible to distinguish, after the trial, the patients who responded positively
to intravenous immunoglobulins. This data, which needs to be confirmed with a controlled trial, provides hope of improved therapy for the one half of patients suffering from adult Still's disease who respond positively to intravenous immunoglobulins.

Registry Numbers: 9007-73-2 (Ferritin)

Institutional address:
      Service de medecine interne
      hopital Saint-Antoine
      Paris
      France.

DISCLAIMER:

The materials and information on this server are intended for educational and informational purposes only. The materials and information are not intended to replace the services of a trained health professional or to be a substitute for medical advice of physicians and/or other health care professionals. The International Still's Disease Foundation is not engaged in rendering medical or professional medical services. You should consult your physician on specific medical questions, particularly in matters requiring diagnosis or medical attention. The International Still's Disease Foundation makes no representations or warranties with respect to any treatment, action, application medication or preparation by any person following the information offered or provided within this website. Any information used from other websites was done so with permission from each site, with an exception to those of "public domain", whereas we believe any site without a cited reference was a "public domain site" and for our use. The International Still's Disease Foundation is a non-profit organization. This page was last updated on June 13, 2002