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Treatment of Still disease in adults with intravenous

Permal S  Wechsler B  Cabane J  
 Perrot S  Blum L  Imbert JC  

Traitement de la maladie de Still de l'adulte par immunoglobulines

In: Rev Med Interne (1995) 16(4):250-4

ISSN: 0248-8663  (Published in French)

In most cases, the treatment of adult's Still disease presents  difficulties, in view of its undesirable side-effects. For this  reason, we made an open trial of the effects of high-dose intravenous  immunoglobulins (IVIg), a therapy with low iatrogen risk, and whose  effectiveness in the treatment of other multisystemic diseases has
 been acknowledged. Seven patients suffering from adult Still's  disease were given between one and eight IVIg infusions with a dose
 of 1 g/kg/day for two consecutive days. All seven responded  positively, with clinical improvement. It lasted between 1 and 90
 days in three patients, who subsequently relapsed; it has been  continuing for an average of 13 months (2 to 24 months) in the other
 four patients. There were no clinical features making it possible to  distinguish, after the trial, the patients who responded positively
 to intravenous immunoglobulins. This data, which needs to be  confirmed with a controlled trial, provides hope of improved therapy  for the one half of patients suffering from adult Still's disease who  respond positively to intravenous immunoglobulins.

Registry Numbers: 9007-73-2 (Ferritin)

Institutional address:
       Service de medecine interne
       hopital Saint-Antoine



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