Make your own free website on Tripod.com

 

Elevated circulating interleukin-7 levels in patients with systemic
juvenile rheumatoid arthritis



De Benedetti F, Massa M, Pignatti P, Kelley M, Faltynek CR, Martini A
Clinica Pediatrica, Universita di Pavia, IRCCS Policlinico S. Matteo,
Italy.

OBJECTIVE. Since interleukin-7 (IL-7) has been shown to induce monocyte
production of IL-1, IL-6, IL-8, and tumor necrosis factor-alpha, we
investigated plasma and synovial fluid levels of IL-7 in patients with
juvenile rheumatoid arthritis (JRA).

METHODS. IL-7 levels were measured using an ELISA in 60 patients with
JRA and in 25 patients with other rheumatic disorders (ORD).

RESULTS. In patients with systemic JRA, but not in patients with
polyarticular or pauciarticular JRA or with ORD, plasma IL-7 levels were
significantly higher (p < 0.0001) than those of healthy controls. IL-7
was undetected in all synovial fluid tested. Among patients with
systemic JRA, those with persistent systemic symptoms had IL-7 levels
significantly higher (p < 0.01) than those of patients in which systemic
symptoms subsided.

CONCLUSION. Plasma IL-7 levels are elevated in patients with systemic
JRA and are associated with the presence and severity of systemic
symptoms.

PMID: 7473488, UI: 96003057


DISCLAIMER:

The materials and information on this server are intended for educational and informational purposes only. The materials and information are not intended to replace the services of a trained health professional or to be a substitute for medical advice of physicians and/or other health care professionals. The International Still's Disease Foundation is not engaged in rendering medical or professional medical services. You should consult your physician on specific medical questions, particularly in matters requiring diagnosis or medical attention. The International Still's Disease Foundation makes no representations or warranties with respect to any treatment, action, application medication or preparation by any person following the information offered or provided within this website.  Any information used from other websites was done so with permission from each site, with an exception to those of "public domain", whereas we believe any site without a cited reference was a "public domain site" and for our use.  The International Still's Disease Foundation is a non-profit organization.   This page was last updated on June 13, 2002

Copyrightę 1999-2002 International Still's Disease Foundation